Myocardial Tissue Engineering [electronic resource] / edited by Aldo R. Boccaccini, Sian E. Harding.
Tipo de material: TextoSeries Studies in Mechanobiology Tissue Engineering and Biomaterials; -6Descripción: X, 268p. 43 illus. online resourceISBN: 9783642180569 99783642180569Tema(s): Engineering | Engineering | CARDIOLOGY | CARDIOLOGY | STEM CELLS | STEM CELLS | GENE THERAPY | GENE THERAPY | BIOCHEMICAL ENGINEERING | BIOCHEMICAL ENGINEERING | BIOMATERIALS | BIOMATERIALSClasificación CDD: 610.28 Recursos en línea: ir a documento Resumen: Myocardial tissue engineering (MTE), a strategy that uses materials or material/cell constructs to prolong patients'life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered "vehicle", which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book also considers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.Tipo de ítem | Ubicación actual | Colección | Signatura | Info Vol | Copia número | Estado | Fecha de vencimiento | Código de barras | Reserva de ítems |
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DOCUMENTOS DIGITALES | Biblioteca Jorge Álvarez Lleras | Digital | 610.28 223 (Navegar estantería) | Ej. 1 | 1 | Disponible | D000563 |
Myocardial tissue engineering (MTE), a strategy that uses materials or material/cell constructs to prolong patients'life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered "vehicle", which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book also considers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.
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